Devilder M C, Cadoret E, Chérel M, Moreau I, Rondeau G, Bézieau S, Moisan J P
Institut de Biologie de l'Hôtel-Dieu, Centre Hospitalier Universitaire, Nantes Cedex, 44093, France.
Genomics. 1998 Nov 15;54(1):99-106. doi: 10.1006/geno.1998.5498.
We report the characterization of a new gene mapped at chromosome band 13q14.3 telomeric to the retinoblastoma gene. This gene, designated CHC1L (for chromosome condensation 1-like), is composed of 14 exons spanning 30 kb of genomic DNA and encodes a ubiquitously expressed 3-kb mRNA. The N-terminal half of the deduced amino acid sequence shows strong homology with the seven tandem repeat structure of the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. CHC1L appears to be a new member of the RCC1-related GEF family.
我们报告了一个新基因的特征，该基因定位于13q14.3染色体带，位于视网膜母细胞瘤基因的端粒侧。这个基因被命名为CHC1L（染色体浓缩1样），由14个外显子组成，跨越30kb的基因组DNA，编码一个广泛表达的3kb mRNA。推导的氨基酸序列的N端一半与染色体浓缩调节因子RCC1的七个串联重复结构显示出强烈的同源性，RCC1作为Ras相关GTP酶Ran的鸟嘌呤核苷酸交换因子（GEF）蛋白。CHC1L似乎是RCC1相关GEF家族的一个新成员。
