Sedgley C M, Samaranayake L P
Oral Bio-science Laboratories, Faculty of Dentistry, University of Hong Kong.
Oral Microbiol Immunol. 1998 Oct;13(5):315-21. doi: 10.1111/j.1399-302x.1998.tb00713.x.
The antibiotic susceptibilities of 59 Enterobacter cloacae and 39 Klebsiella pneumoniae human oral isolates collected from a southern Chinese population in Hong Kong were investigated for their susceptibility to eight antibiotics: ampicillin, cephalothin, cefuroxime, ceftazidime, ciprofloxacin, gentamicin, tetracycline and trimethoprim/sulfamethoxazole using the E-Test method for direct quantification of minimum inhibitory concentrations. Most strains were sensitive to all antibiotics except ampicillin and cephalothin. Ampicillin resistance was exhibited by 82% of K. pneumoniae and 69% of E. cloacae isolates. Eighty-eight percent of E. cloacae isolates were resistant to cephalothin. Several strains fell within the intermediate category of sensitivity for ampicillin (E. cloacae and K. pneumoniae), cefuroxime (E. cloacae) and tetracycline (K. pneumoniae). Comparison with other Hong Kong data suggests that resistance rates to cefuroxime, ceftazidime, ciprofloxacin, gentamicin, tetracycline and trimethoprim/sulfamethoxazole exhibited by the oral isolates are generally lower than in enterobacters and Klebsiella spp. isolated from urine, skin and soft tissues in Hong Kong populations.
利用E-Test方法直接定量测定最低抑菌浓度，对从中国香港南方人群中收集的59株阴沟肠杆菌和39株肺炎克雷伯菌口腔分离株进行了8种抗生素敏感性研究，这8种抗生素分别为氨苄西林、头孢噻吩、头孢呋辛、头孢他啶、环丙沙星、庆大霉素、四环素和甲氧苄啶/磺胺甲恶唑。除氨苄西林和头孢噻吩外，大多数菌株对所有抗生素敏感。82%的肺炎克雷伯菌分离株和69%的阴沟肠杆菌分离株表现出对氨苄西林耐药。88%的阴沟肠杆菌分离株对头孢噻吩耐药。有几株菌株对氨苄西林（阴沟肠杆菌和肺炎克雷伯菌）、头孢呋辛（阴沟肠杆菌）和四环素（肺炎克雷伯菌）的敏感性属于中等类别。与香港其他数据比较表明，口腔分离株对头孢呋辛、头孢他啶、环丙沙星、庆大霉素、四环素和甲氧苄啶/磺胺甲恶唑的耐药率通常低于从香港人群尿液、皮肤和软组织分离出的肠杆菌和克雷伯菌属。
