Rubinow D R, Schmidt P J, Roca C A
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, Maryland 20892-1276, USA.
Biol Psychiatry. 1998 Nov 1;44(9):839-50. doi: 10.1016/s0006-3223(98)00162-0.
A burgeoning literature documents the convergence of reproductive endocrine and central serotonergic systems in the regulation of a variety of behaviors. This review will focus on one element of this interaction, the modulation of serotonergic function by estrogen. After describing the manifold neuroregulatory effects of gonadal steroids, we summarize the effects of estrogen on central serotonin systems in animals and humans as inferred from studies demonstrating the impact of gender, estrus (or menstrual) cycle, or hormone manipulation. Finally, we summarize the putative roles of estrogen and serotonin in two reproductive-endocrine-related mood disorders: premenstrual syndrome and perimenopausal depression.
大量文献记载了生殖内分泌系统和中枢5-羟色胺能系统在调节多种行为方面的相互作用。本综述将聚焦于这种相互作用的一个方面，即雌激素对5-羟色胺能功能的调节。在描述性腺类固醇的多种神经调节作用之后，我们将根据有关性别、发情（或月经）周期或激素调控影响的研究，总结雌激素对动物和人类中枢5-羟色胺系统的影响。最后，我们将总结雌激素和5-羟色胺在两种与生殖内分泌相关的情绪障碍——经前综合征和围绝经期抑郁症中的假定作用。
