日本人群中一元胺氧化酶-A基因与重度精神病
The monoamine oxidase-A gene and major psychosis in Japanese subjects.
作者信息
Sasaki T, Hattori M, Sakai T, Kato T, Kunugi H, Hirose T, Nanko S
机构信息
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
出版信息
Biol Psychiatry. 1998 Nov 1;44(9):922-4. doi: 10.1016/s0006-3223(97)00522-2.
BACKGROUND
Monoamine oxidase (MAO) is a critical enzyme in deamination of biogenic amines and may be involved in the pathophysiology of major psychosis, including mood disorder and schizophrenia. Recently, evidence for genetic association between the MAO-A gene and bipolar mood disorder was obtained in Caucasians.
METHODS
We investigated the polymorphisms of the MAO-A gene, which may be related to enzyme activity (T/941/G, A/1609/G), with amino-acid change (A/1609/G), in Japanese patients with bipolar disorder patients (n = 132), unipolar major depression (n = 43), or schizophrenia (n = 95), and controls (n = 169).
RESULTS
No difference in the allele frequencies or genotype distribution of the T/941/G variation was observed between any disease group and the control group. As for the A/1609/G variation, no G allele was found in the Japanese subjects.
CONCLUSIONS
No evidence for the genetic association between the MAO-A gene and major psychosis was obtained in the Japanese subjects.
背景
单胺氧化酶（MAO）是生物胺脱氨基过程中的关键酶，可能参与包括情绪障碍和精神分裂症在内的主要精神病的病理生理过程。最近，在白种人中获得了MAO - A基因与双相情感障碍之间存在遗传关联的证据。
方法
我们调查了日本双相情感障碍患者（n = 132）、单相重度抑郁症患者（n = 43）、精神分裂症患者（n = 95）及对照组（n = 169）中MAO - A基因的多态性，这些多态性可能与酶活性相关（T/941/G、A/1609/G），且A/1609/G存在氨基酸变化。
结果
在任何疾病组与对照组之间，未观察到T/941/G变异的等位基因频率或基因型分布存在差异。至于A/1609/G变异，在日本受试者中未发现G等位基因。
结论
在日本受试者中，未获得MAO - A基因与主要精神病之间存在遗传关联的证据。
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