Schulze T G, Müller D J, Krauss H, Scherk H, Ohlraun S, Syagailo Y V, Windemuth C, Neidt H, Grässle M, Papassotiropoulos A, Heun R, Nöthen M M, Maier W, Lesch K P, Rietschel M
Department of Psychiatry, University of Bonn, Bonn, Germany.
Am J Med Genet. 2000 Dec 4;96(6):801-3.
Various polymorphisms of the X-chromosomal monoamine oxidase A (MAO-A) gene were investigated for association with affective disorders. However, none of the studied variants could consistently be associated with either major depressive or bipolar affective disorder. Recently, a positive association between panic disorder and a novel functional repeat polymorphism in the MAO-A gene promoter, with the longer alleles being more active, was reported. Since monoaminergic neurotransmission is supposed to play an important role in affective disorders, we investigated a potential association of this polymorphism with major depressive illness in a sample of 146 unrelated patients of German descent and a control group of 101 individuals with a negative life history for affective disorders. Similarly to the recent findings in panic disorder, we observed a significantly increased frequency of genotypes containing only long alleles in female patients with recurrent major depression in comparison with age- and sex-matched controls. Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000.
研究了X染色体单胺氧化酶A（MAO-A）基因的各种多态性与情感障碍的关联。然而，所研究的变体均不能始终如一地与重度抑郁症或双相情感障碍相关联。最近，有报道称惊恐障碍与MAO-A基因启动子中的一种新型功能性重复多态性之间存在正相关，较长的等位基因活性更高。由于单胺能神经传递被认为在情感障碍中起重要作用，我们在146名德国血统的无亲缘关系患者样本和101名情感障碍阴性病史个体的对照组中，研究了这种多态性与重度抑郁症的潜在关联。与惊恐障碍的最新研究结果相似，我们观察到与年龄和性别匹配的对照组相比，复发性重度抑郁症女性患者中仅包含长等位基因的基因型频率显著增加。因此，我们的数据表明，导致MAO-A活性升高的高活性MAO-A基因启动子等位基因过多是女性重度抑郁症的一个危险因素。《美国医学遗传学杂志》（神经精神遗传学）96:801 - 803，2000年。
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