Dusso A S, Brown A J
Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA.
Am J Kidney Dis. 1998 Oct;32(2 Suppl 2):S13-24. doi: 10.1053/ajkd.1998.v32.pm9808140.
Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. The VDR functions as a ligand-induced transcription factor regulating the rate of expression of genes involved not only in the control of calcium homeostasis and bone remodeling, but also in immunomodulation, the control of hormone secretion, Inhibition of cell growth, and induction of cell differentiation. This section discusses the molecular mechanisms involved in the transcriptional control of gene expression by 1,25(OH)2D3.
1,25(OH)2D3是维生素D的激素形式，其大部分生物学作用是由维生素D受体（VDR）介导的，VDR是类固醇/甲状腺受体超家族的成员。VDR作为一种配体诱导的转录因子，不仅调节参与钙稳态和骨重塑控制的基因的表达速率，还调节免疫调节、激素分泌控制、细胞生长抑制和细胞分化诱导等相关基因的表达速率。本节讨论1,25(OH)2D3对基因表达进行转录控制所涉及的分子机制。
