Sadeghi Masoud, Golshah Amin, Godiny Mostafa, Sharifi Roohollah, Khavid Atefeh, Nikkerdar Nafiseh, Tadakamadla Santosh Kumar
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran.
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
Children (Basel). 2021 Apr 15;8(4):302. doi: 10.3390/children8040302.
Vitamin D participates in the calcification of enamel and dentin and the appropriate immune responses to oral microbial infections. We aimed to assess the association between the most common vitamin D receptor () polymorphisms (, , , and ) and the risk of dental caries in children.
PubMed/MEDLINE, Cochrane Library, Web of Science, and Scopus databases were comprehensively searched until 19 January 2021. Meta-analysis with odds ratios as the effect estimate along with 95% confidence intervals and subgroup analysis were conducted using Review Manager 5.3 software. Publication bias and sensitivity analyses were conducted by Comprehensive Meta-Analysis, version 2.0 software.
Seventy-eight studies were retrieved from the databases, with nine studies included in the final analysis. Based on five genetic models, there was no association between , , , , and polymorphisms and susceptibility to dental caries, except for the polymorphism.
Among the polymorphisms considered, an association was found between the polymorphism and the risk of dental caries, with a protective role of the f allele and ff genotype.
维生素D参与牙釉质和牙本质的钙化以及对口腔微生物感染的适当免疫反应。我们旨在评估最常见的维生素D受体（）多态性（、、、和）与儿童龋齿风险之间的关联。
全面检索了PubMed/MEDLINE、Cochrane图书馆、Web of Science和Scopus数据库，直至2021年1月19日。使用Review Manager 5.3软件进行以比值比作为效应估计值并伴有95%置信区间的荟萃分析以及亚组分析。通过Comprehensive Meta-Analysis 2.0软件进行发表偏倚和敏感性分析。
从数据库中检索到78项研究，最终分析纳入9项研究。基于五种遗传模型，除了多态性外，、、、和多态性与龋齿易感性之间无关联。
在所考虑的多态性中，发现多态性与龋齿风险之间存在关联，f等位基因和ff基因型具有保护作用。
