Chin G N, Goodman N L
Ann Ophthalmol. 1978 Apr;10(4):415-8.
Corneal infection due to the species Aspergillus flavus is rare and often destructive. This report describes a case of Aspergillus flavus corneal ulcer that failed to respond to amphotericin B, pimaricin, and clotrimazole. The eye subsequently became phthisical. The rational approach to the management of fungal corneal infection is to culture or perform sensitivity tests on the isolated organism. Early surgical intervention should be done if the infection fails to respond to medical treatment, and if the disease process extends deep into the stromal tissue and anterior chamber. Fungal malignant glaucoma requires excisional keratoplasty, lens extraction, and anterior vitrectomy.
黄曲霉引起的角膜感染较为罕见，但往往具有破坏性。本报告描述了一例对两性霉素B、匹马霉素和克霉唑治疗无效的黄曲霉角膜溃疡病例。该眼随后萎缩。真菌性角膜感染的合理治疗方法是对分离出的病原体进行培养或药敏试验。如果感染对药物治疗无反应，且疾病进程深入到基质组织和前房，则应尽早进行手术干预。真菌性恶性青光眼需要进行切除性角膜移植术、晶状体摘除术和前部玻璃体切除术。
