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[透明细胞肾细胞癌20年潜伏期后出现孤立性转移,临床症状类似血管肿瘤]

[Solitary metastasis of a clear cell renal cell carcinoma after a 20 year latency clinically simulating a vascular tumor].

作者信息

Rothfuss-Kikillus X, Torsello G, Kasprzak B, Edel G

机构信息

Abteilung für Gefässchirurgie, St. Franziskus-Hospital Münster.

出版信息

Dtsch Med Wochenschr. 1998 Oct 16;123(42):1239-42. doi: 10.1055/s-2007-1024163.

Abstract

HISTORY AND CLINICAL FINDINGS

A 72-year-old woman was referred because of progressive skin discoloration with venectasia and swelling in the left lower leg, the possible diagnosis being atypical varicose veins. 20 years before she had a right nephrectomy for "clear-cell" renal adenocarcinoma with subsequent tele-cobalt radiotherapy. On examination a pulsating swelling was palpated over the hyperpigmented area of the skin with venectasia.

INVESTIGATIONS

She had hypercholesterolaemia (254 mg/dl) and hyperuricaemia (uric acid 6.2 mg/dl). Duplex sonography, angiography and computed tomography of the lower leg revealed a vascular tumour with infiltration of the right head of the gastrocnemius.

DIAGNOSIS, TREATMENT AND COURSE: Because an arteriovenous fistula within a vascular soft-tissue tumour of unknown histology was suspected, a wide resection was performed. Histopathological examination revealed a metastasis of a clear-cell adenocarcinoma. Postoperative diagnostic tests discovered no other findings suspicious of malignancy. It is therefore to be assumed that the resected tumour was a solitary metastasis of the renal adenocarcinoma removed 20 years previously.

CONCLUSION

Even rare causes should be considered in the differential diagnosis of vascular tumour, as this case of a solitary metastasis after a latency of 20 years demonstrates.

摘要

病史及临床检查结果

一名72岁女性因左下肢皮肤进行性变色伴静脉曲张及肿胀前来就诊,可能诊断为非典型静脉曲张。20年前,她因“透明细胞”肾腺癌接受了右肾切除术,随后接受了远距钴放疗。检查时,在有静脉曲张的皮肤色素沉着区域可触及一个搏动性肿块。

检查

她患有高胆固醇血症(254毫克/分升)和高尿酸血症(尿酸6.2毫克/分升)。小腿的双功超声、血管造影和计算机断层扫描显示有一个血管肿瘤,腓肠肌右头受浸润。

诊断、治疗及病程:由于怀疑在组织学不明的血管软组织肿瘤内存在动静脉瘘,遂进行了广泛切除。组织病理学检查显示为透明细胞腺癌转移。术后诊断检查未发现其他可疑恶性病变。因此,可以认为切除的肿瘤是20年前切除的肾腺癌的孤立转移灶。

结论

正如这个20年后出现孤立转移的病例所示,在血管肿瘤的鉴别诊断中,即使是罕见病因也应予以考虑。

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