Itokazu M, Aoki T, Nonomura H, Nishimoto Y, Itoh Y
Department of Orthopaedic Surgery, Gifu University School of Medicine, Japan.
Bull Hosp Jt Dis. 1998;57(3):125-9.
Hydroxyapatite blocks (HAB) can be used to administer antibiotics or anticancer drugs because its porous structure allows the gradual administration of the pharmacologic agents. A novel drug delivery system using hydroxyapatite blocks was developed for osteomyelitis and postoperative infections occurring after joint replacement. To load the antibiotics, hydroxyapatite blocks were mixed with an antibiotic solution and centrifuged at 1500 rpm for 15 minutes or decompressed in vacuum container at 5 to 10 in. Hg for 20 minutes. Fifteen patients with osteomyelitis including one with tuberculosis and four with infections subsequent to joint replacement were treated with antibiotic-loaded hydroxyapatite blocks in combination with intravenous injection. Except in one case, all of the foci had completely healed at follow-up (range: 13 to 71 months; average: 39.7 months). These new methods are simple and can safely treat osteomyelitis in a one-stage operation.
羟基磷灰石块（HAB）可用于施用抗生素或抗癌药物，因为其多孔结构允许药理剂逐渐释放。一种使用羟基磷灰石块的新型药物递送系统被开发用于治疗骨髓炎和关节置换术后感染。为了加载抗生素，将羟基磷灰石块与抗生素溶液混合，并以1500转/分钟的速度离心15分钟，或在5至10英寸汞柱的真空容器中减压20分钟。15例骨髓炎患者，包括1例结核病患者和4例关节置换术后感染患者，接受了负载抗生素的羟基磷灰石块治疗并结合静脉注射。除1例患者外，所有病灶在随访时（范围：13至71个月；平均：39.7个月）均已完全愈合。这些新方法简单，并且可以在一期手术中安全地治疗骨髓炎。
