Sem'yanov A V, Kalemenev S V, Godukhin O V
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast, Russia.
Neurosci Behav Physiol. 1998 Sep-Oct;28(5):504-12. doi: 10.1007/BF02463010.
Transient periodic increases in the extracellular K+ concentration (20 mM, 30 sec, 3-6 episodes) led to the appearance of a kindling-like state in local neuronal networks of field CA1 of rat hippocampal slices. A criterion for the appearance of this state was a reduction in the threshold for the generation of multiple population discharges and an increase in the total number of population spikes within discharges (epileptiform activity). This state correlated with potentiation of excitatory postsynaptic potentials (EPSP) (long-term increases in pyramidal neuron excitability), but not with potentiation of glutamatergic synaptic transmission in field CA1 of hippocampal slices. The role of the various Ca2+ channels in inducing and maintaining the kindling-like state in rat hippocampal sections, evoked by periodic increases in the extracellular K+ concentration, is discussed.
细胞外钾离子浓度的短暂周期性升高（20毫摩尔，30秒，3 - 6次发作）导致大鼠海马切片CA1区局部神经网络中出现类点燃状态。这种状态出现的一个标准是产生多个群体放电的阈值降低以及放电内群体峰电位总数增加（癫痫样活动）。这种状态与兴奋性突触后电位（EPSP）的增强相关（锥体神经元兴奋性长期增加），但与海马切片CA1区谷氨酸能突触传递的增强无关。讨论了各种钙离子通道在细胞外钾离子浓度周期性升高诱发和维持大鼠海马切片类点燃状态中的作用。
