Ueshiba H, Kato H, Miyoshi-Akiyama T, Tsubokura M, Nagano T, Kaneko S, Uchiyama T
Institute of Laboratory Animals, Tokyo Women's Medical College, Japan.
Zentralbl Bakteriol. 1998 Oct;288(2):277-91. doi: 10.1016/s0934-8840(98)80051-0.
Yersinia pseudotuberculosis is a pathogen causing gastroenteritis as well as acute and systemic infections. This organism produces a superantigenic exotoxin, designated Y. pseudotuberculosis-derived mitogen (YPM). We consider this exotoxin to be the primary pathogen of the systemic type infection. In this study, we examined 101 Y. pseudotuberculosis strains isolated from various sources, patients with the systemic or the gastroenteric type of infections, wildlife animals and natural environments for the presence of the YPM gene and the production of YPM or other related superantigens. We found that all of the strains isolated from patients with systemic type infection carried the YPM gene and produced YPM. A certain proportion of the organisms isolated from patients with the gastroenteric type infection, wildlife animals or natural environments did not carry the YPM gene nor produced superantigens. These results suggest that YPM is involved in the pathogenesis of the systemic type of Y. pseudotuberculosis infection.
假结核耶尔森菌是一种可引发肠胃炎以及急性和全身性感染的病原体。这种微生物会产生一种超抗原性外毒素，称为假结核耶尔森菌衍生丝裂原（YPM）。我们认为这种外毒素是全身性感染类型的主要病原体。在本研究中，我们检测了从各种来源分离出的101株假结核耶尔森菌菌株，这些菌株来自全身性或肠胃型感染患者、野生动物以及自然环境，检测其是否存在YPM基因以及是否产生YPM或其他相关超抗原。我们发现，从全身性感染患者中分离出的所有菌株都携带YPM基因并产生YPM。从肠胃型感染患者、野生动物或自然环境中分离出的一定比例的微生物既不携带YPM基因，也不产生超抗原。这些结果表明，YPM参与了假结核耶尔森菌全身性感染的发病机制。
