格拉司琼及其与地塞米松联合使用对雪貂顺铂诱导的迟发性呕吐的影响。

Effects of granisetron and its combination with dexamethasone on cisplatin-induced delayed emesis in the ferret.

Fukunaka N, Sagae S, Kudo R, Endo T, Hirafuji M, Minami M

Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Japan.

Gen Pharmacol. 1998 Nov;31(5):775-81. doi: 10.1016/s0306-3623(98)00102-5.

Abstract

Granisetron and its combination with dexamethasone for the treatment of delayed emesis following cisplatin (CDDP) administration were investigated using ferrets. 2. CDDP-induced emesis was significantly inhibited in both the granisetron group and the combined granisetron and dexamethasone group during the acute and delayed phase in terms of total emesis, latency to first emesis and duration of emesis. 3. Food and water consumption in the combined group of ferrets was significantly increased as compared with the CDDP control group. 4. 5-Hydroxytryptamine (5-HT) level was increased in the ileum and the 5-hydroxyindole acetic acid (5-HIAA) level was increased in the area postrema of ferrets after 3 days of CDDP administration. It is suggested that the antiemetic activity of granisetron and/or dexamethasone is not related to 5-HT levels in delayed emesis. 5. Both granisetron and its combination with dexamethasone are effective in CDDP-induced emesis, but combination treatment is more effective than granisetron alone for the duration of emesis in the delayed phase.

摘要

使用雪貂研究了格拉司琼及其与地塞米松联合用于治疗顺铂（CDDP）给药后延迟性呕吐的效果。2. 在急性和延迟期，就总呕吐次数、首次呕吐潜伏期和呕吐持续时间而言，格拉司琼组以及格拉司琼与地塞米松联合组中CDDP诱导的呕吐均受到显著抑制。3. 与CDDP对照组相比，联合用药组雪貂的食物和水消耗量显著增加。4. CDDP给药3天后，雪貂回肠中的5-羟色胺（5-HT）水平升高，最后区中的5-羟吲哚乙酸（5-HIAA）水平升高。提示格拉司琼和/或地塞米松的止吐活性与延迟性呕吐中的5-HT水平无关。5. 格拉司琼及其与地塞米松联合用药对CDDP诱导的呕吐均有效，但联合治疗在延迟期呕吐持续时间方面比单独使用格拉司琼更有效。