Perry H M, Bernard M, Horowitz M, Miller D K, Fleming S, Baker M Z, Flaherty J, Purushothaman R, Hajjar R, Kaiser F E, Patrick P, Morley J E
GRECC, St. Louis VA Medical Center, Jefferson Barracks, St. Louis University Medical School, Missouri, USA.
J Am Geriatr Soc. 1998 Nov;46(11):1418-22. doi: 10.1111/j.1532-5415.1998.tb06010.x.
To examine the effect of age on mineral metabolism and bone mineral density (BMD) of the hip and spine in Native American women.
A cross-sectional study.
The Sac and Fox Nation in rural Oklahoma
Serum measurements were made of 25 hydroxyvitamin D (25OHD), osteocalcin, and immunoreactive parathyroid hormone. Bone mineral density of the hip and spine was assessed by dual energy X-ray absorptiometry.
A total of 77 Native American women aged 19 to 85 years.
Serum 25 hydroxyvitamin D was related inversely to age (r = -0.32; P < .05) and was less than 15 ng/mL in 7% of the subjects. Serum osteocalcin was higher (P < .001) in postmenopausal than in premenopausal subjects. In postmenopausal subjects, serum osteocalcin was related to age (r = .59, P < .001). BMD was lower (P < .001) in postmenopausal than in premenopausal subjects. There was no evidence of bone loss before age 50 in either the femur or the spine. Age (r > or = -0.48, P < .001) and body mass index (BMI) (r > or = 0.41, P < .005) were independent determinants of both femoral and lumbar BMD. Serum 25OHD was a significant independent determinant of both lumbar (r = .26, P < .05) and femoral (r = .41, P < .01) BMD. Age, BMI, and serum 25OHD together accounted for 70% of the variance in BMD at these sites. The use of t scores indicated femoral bone density was higher (P < .05) in premenopausal Native American women, and lower (P < 0.05) in postmenopausal subjects, compared with white women.
In Native American women, there is a reduction in bone density and a sustained increase in bone turnover postmenopausally. BMI and serum 25OHD are significant determinants of BMD. Peak BMD may be higher, and the postmenopausal rate of bone loss greater, than that in white women.
研究年龄对美国原住民女性矿物质代谢及髋部和脊柱骨密度（BMD）的影响。
横断面研究。
俄克拉荷马州农村的萨克和福克斯部落
检测血清25羟维生素D（25OHD）、骨钙素和免疫反应性甲状旁腺激素。采用双能X线吸收法评估髋部和脊柱的骨密度。
共77名年龄在19至85岁之间的美国原住民女性。
血清25羟维生素D与年龄呈负相关（r = -0.32；P <.05），7%的研究对象血清25羟维生素D水平低于15 ng/mL。绝经后女性血清骨钙素水平高于绝经前女性（P <.001）。在绝经后女性中，血清骨钙素与年龄相关（r =.59，P <.001）。绝经后女性的骨密度低于绝经前女性（P <.001）。在50岁之前，股骨或脊柱均未出现骨质流失。年龄（r ≥ -0.48，P <.001）和体重指数（BMI）（r ≥ 0.41，P <.005）是股骨和腰椎骨密度的独立决定因素。血清25OHD是腰椎（r =.26，P <.05）和股骨（r =.41，P <.01）骨密度的重要独立决定因素。年龄、BMI和血清25OHD共同解释了这些部位骨密度变异的70%。使用t值表明，与白人女性相比，绝经前美国原住民女性的股骨骨密度更高（P <.05），绝经后女性的股骨骨密度更低（P < 0.05）。
在美国原住民女性中，绝经后骨密度降低，骨转换持续增加。BMI和血清25OHD是骨密度的重要决定因素。其骨密度峰值可能高于白人女性，绝经后骨质流失率可能也高于白人女性。
