Korsić M, Jelasić D, Potocki K, Giljević Z, Aganović I
Department of Medicine, University Hospital Rebro, Zagreb, Croatia.
Skeletal Radiol. 1998 Sep;27(9):525-8. doi: 10.1007/s002560050433.
A rare case of massive osteolysis affecting the pelvis of a young girl is presented. The clinical, radiographic, and histopathological features are described in detail. Septicemia complicated the clinical course and the patient eventually died. Histopathological examination of the pelvic lesion revealed massive osteolysis characterized by prominent osteoclastic activity with extensive bone resorption. A thorough post-mortem histological examination of the thyroid gland showed no C cells. This is an interesting observation, since it is known that thyroid C cells are the primary source of calcitonin. Since the main biological effect of calcitonin is to inhibit osteoclastic bone resorption, there is a possibility that massive osteolysis in our case could have been related to the lack of this hormone. There is a clear need for further investigation regarding the role of thyroid C cells and calcitonin in this puzzling disease.
本文报道了一例罕见的影响年轻女孩骨盆的大面积骨质溶解病例。详细描述了其临床、影像学和组织病理学特征。败血症使临床病程复杂化，患者最终死亡。骨盆病变的组织病理学检查显示大面积骨质溶解，其特征为破骨细胞活性显著，伴有广泛的骨吸收。对甲状腺进行的全面尸检组织学检查未发现C细胞。这是一个有趣的发现，因为已知甲状腺C细胞是降钙素的主要来源。由于降钙素的主要生物学作用是抑制破骨细胞的骨吸收，因此我们病例中的大面积骨质溶解有可能与这种激素的缺乏有关。显然有必要进一步研究甲状腺C细胞和降钙素在这种疑难疾病中的作用。
