Fujita T, Matsui M, Takaku K, Uetake H, Ichikawa W, Taketo M M, Sugihara K
Second Department of Surgery, Tokyo Medical and Dental University, Japan.
Cancer Res. 1998 Nov 1;58(21):4823-6.
Nonsteroidal anti-inflammatory drugs reduce the incidence and mortality of colorectal carcinoma. Their chemopreventive effects appear to be due to inhibition of cyclooxygenase (COX)-2. Here, we have studied the relationship between the COX-2 mRNA levels and pathological characteristics in 43 primary colorectal carcinomas. COX-2 levels were significantly higher in tumors with larger sizes and in those with deeper invasions but were not correlated with whether the patients had metastasis or not. These results suggest that larger carcinomas produce more COX-2 to support their own growth and that COX-2 inhibitors may be effective agents of carcinoma growth suppression.
非甾体抗炎药可降低结直肠癌的发病率和死亡率。它们的化学预防作用似乎是由于抑制了环氧化酶（COX）-2。在此，我们研究了43例原发性结直肠癌中COX-2 mRNA水平与病理特征之间的关系。COX-2水平在肿瘤体积较大和浸润较深的肿瘤中显著更高，但与患者是否发生转移无关。这些结果表明，较大的癌产生更多的COX-2以支持自身生长，并且COX-2抑制剂可能是抑制癌生长的有效药物。
