Gozal D
Constance S. Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
Pediatr Pulmonol. 1998 Oct;26(4):273-82. doi: 10.1002/(sici)1099-0496(199810)26:4<273::aid-ppul7>3.0.co;2-c.
Awareness of the existence of CCHS has led to increasingly frequent reports of such patients from all over the world. However, the exact pathophysiologic mechanisms underlying the clinical manifestations of this congenital disease entity remain unknown. For the respiratory physiologist, CCHS can be viewed as an experiment of nature that provides an important and unique window into central cardiorespiratory regulation. For the pediatrician, CCHS children represent an unique clinical challenge in coordinating the diagnostic and therapeutic procedures required to enhance the patients' quality of life.
对先天性中枢性低通气综合征（CCHS）存在的认识，已导致来自世界各地关于此类患者的报告日益频繁。然而，这种先天性疾病实体临床表现背后的确切病理生理机制仍不清楚。对于呼吸生理学家而言，CCHS可被视为一种自然实验，它为深入了解中枢心肺调节提供了一个重要且独特的窗口。对于儿科医生来说，CCHS患儿在协调提高患者生活质量所需的诊断和治疗程序方面，代表着一项独特的临床挑战。
