Askew D S, Heffelfinger S
Department of Pathology and Laboratory Medicine at the University of Cincinnati, OH 45267-0529, USA.
Anat Rec. 1998 Oct;253(5):143-6. doi: 10.1002/(SICI)1097-0185(199810)253:5<143::AID-AR7>3.0.CO;2-7.
One of the most striking changes to affect the direction of current biomedical research is the increasing use of transgenic or gene-targeted mice as models of gene function and human disease. The proliferation of transgenic and gene-targeting technology has contributed to a rebirth of histology as an important research tool and is driving the need for broadly trained investigators with expertise at both the molecular and organismal levels. Since the ultimate goal of graduate-student education is the training of the next generation of independent scientists, it is important that graduate training programs provide students with the background required to take advantage of the unique resources provided by these mouse models. Anatomists are well suited to provide such training by incorporating mouse anatomy, physiology, and genetics into traditional coursework in microscopic anatomy.
影响当前生物医学研究方向的最显著变化之一，是越来越多地使用转基因或基因靶向小鼠作为基因功能和人类疾病的模型。转基因和基因靶向技术的普及促成了组织学作为一种重要研究工具的复兴，并促使需要在分子和生物体水平上都具有专业知识的经过广泛培训的研究人员。由于研究生教育的最终目标是培养下一代独立科学家，因此研究生培训项目为学生提供利用这些小鼠模型所提供的独特资源所需的背景知识非常重要。解剖学家非常适合通过将小鼠解剖学、生理学和遗传学纳入微观解剖学的传统课程中来提供此类培训。
