O'Connor M E, Schmidt W, Carroll-Pankhurst C, Olness K N
Department of Pediatrics, Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, Ohio 44106-6019, USA.
Arch Pediatr Adolesc Med. 1998 Nov;152(11):1065-70. doi: 10.1001/archpedi.152.11.1065.
To evaluate the hypothesis that breast-feeding women who participate in relaxation training will have increased secretory IgA (sIgA) levels in their breast milk compared with women not receiving training.
Nonrandomized control trial of a convenience sample.
Women were recruited from the postpartum floor of a university teaching hospital. The intervention took place in the women's homes.
Women in the first 48 hours after delivery who were planning to breast-feed their healthy newborn infants for at least 8 weeks were approached for enrollment. Women were excluded if they had previous experience with relaxation training. At 4 to 6 weeks postpartum, we enrolled 38 women still breast-feeding their infants.
Women were allocated into 3 groups. Women in group 1 were taught relaxation and had breast milk samples collected before and after the teaching. Women in group 2 had conversation with similar breast milk sample collection, and women in group 3 had 1 breast milk sample collected. Women in group 1 were encouraged to practice the relaxation once or twice a day for 2 weeks, and a second visit was made to all mothers with repeated breast milk collections. Women who were still breast-feeding at 6 to 8 weeks after study end had a final breast milk sample collected. Breast milk was analyzed for secretory IgA levels. Stress was assayed using the Symptom Checklist-90-R and open-ended questions.
There was no difference in sIgA levels among the 3 groups at any time. Women who reported stress present between visit 1 and visit 2 increased their sIgA levels at the final sample collection (+0.16 g/L) compared with women who reported no stress (-0.09 g/L; P= .03). The ratings of success in relaxation in women in group 1 were related to the following sIgA levels in sample 4: poor relaxation, 0.67 g/L; fair relaxation, 0.41 g/L; good relaxation, 0.35 g/L; and very good, 0.30 g/L (P= .006).
Self-reported stress appears to increase breast milk sIgA levels. Success at relaxation was inversely related to sIgA levels in the group learning relaxation.
评估这样一种假设，即与未接受训练的女性相比，参与放松训练的母乳喂养女性母乳中的分泌型免疫球蛋白A（sIgA）水平会升高。
对便利样本进行的非随机对照试验。
从一所大学教学医院的产后病房招募女性。干预在女性家中进行。
产后48小时内计划对其健康新生儿进行至少8周母乳喂养的女性被邀请参与研究。有过放松训练经验的女性被排除。产后4至6周时，我们招募了38名仍在母乳喂养婴儿的女性。
女性被分为3组。第1组女性接受放松训练，并在训练前后采集母乳样本。第2组女性进行类似的对话并采集母乳样本，第3组女性采集1次母乳样本。鼓励第1组女性每天练习放松1至2次，持续2周，之后再次拜访所有母亲并重复采集母乳样本。研究结束后6至8周仍在母乳喂养的女性采集最后一次母乳样本。分析母乳中的分泌型免疫球蛋白A水平。使用症状自评量表90修订版（Symptom Checklist-90-R）和开放式问题评估压力。
3组在任何时间的sIgA水平均无差异。报告在第1次和第2次拜访期间有压力的女性，与报告无压力的女性相比，在最后一次样本采集时sIgA水平升高（+0.16 g/L），而后者sIgA水平下降（-0.09 g/L；P = 0.03）。第1组女性放松训练的成功程度与样本4中的sIgA水平相关：放松效果差，0.67 g/L；放松效果一般，0.41 g/L；放松效果好，0.35 g/L；放松效果非常好，0.30 g/L（P = 0.006）。
自我报告的压力似乎会增加母乳中的sIgA水平。在学习放松的组中，放松的成功程度与sIgA水平呈负相关。
