脑膜炎奈瑟菌血红蛋白-触珠蛋白利用系统HpuAB对完整卟啉的转运
Transport of intact porphyrin by HpuAB, the hemoglobin-haptoglobin utilization system of Neisseria meningitidis.
作者信息
Lewis L A, Sung M H, Gipson M, Hartman K, Dyer D W
机构信息
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73103, USA.
出版信息
J Bacteriol. 1998 Nov;180(22):6043-7. doi: 10.1128/JB.180.22.6043-6047.1998.
Abstract
The meningococcal hemA gene was cloned and used to construct a porphyrin biosynthesis mutant. An analysis of the hemA mutant indicated that meningococci can transport intact porphyrin from heme (Hm), hemoglobin (Hb), and Hb-haptoglobin (Hp). By constructing a HemA- HpuAB- double mutant, we demonstrated that HpuAB is required for the transport of porphyrin from Hb and Hb-Hp.
摘要
脑膜炎球菌hemA基因被克隆并用于构建卟啉生物合成突变体。对hemA突变体的分析表明，脑膜炎球菌能够从血红素（Hm）、血红蛋白（Hb）和血红蛋白-触珠蛋白（Hp）转运完整的卟啉。通过构建HemA-HpuAB双突变体，我们证明了HpuAB是从Hb和Hb-Hp转运卟啉所必需的。
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