Sunyecz J A, Wiesenfeld H C, Heine R P
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine/Magee-Womens Research Institute, PA, USA.
Infect Dis Obstet Gynecol. 1998;6(4):160-2. doi: 10.1002/(SICI)1098-0997(1998)6:4<160::AID-IDOG4>3.0.CO;2-C.
To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin in women with postpartum endometritis.
Gentamicin in a single daily dose of 4.5 mg/kg was administered intravenously to 10 women with postpartum endometritis. Peak and trough gentamicin levels were measured, and nephrotoxicity and clinical ototoxicity were monitored. Pharmacokinetic data were analyzed, and a cost analysis of once-daily gentamicin administration was performed.
The mean elimination constant was 0.105 +/- 0.008 L/h, and the mean volume of distribution was 0.34 +/- 0.07 L/kg. Mean peak gentamicin levels exceeded 11 mg/L, and all trough levels were < 0.3 mg/L. Cost savings of 44% were achieved with once-daily dosing of gentamicin, compared with traditional thrice-daily dosing.
Once-daily dosing with gentamicin in women with postpartum endometritis achieves therapeutic peak levels without drug accumulation. Substantial cost savings are realized with this dosing regimen.
评估庆大霉素每日一次给药方案在产后子宫内膜炎女性患者中的药代动力学及成本。
对10例产后子宫内膜炎女性患者静脉注射单剂量4.5mg/kg的庆大霉素。测定庆大霉素的峰浓度和谷浓度，并监测肾毒性和临床耳毒性。分析药代动力学数据，并对庆大霉素每日一次给药进行成本分析。
平均消除常数为0.105±0.008L/h，平均分布容积为0.34±0.07L/kg。庆大霉素平均峰浓度超过11mg/L，所有谷浓度均<0.3mg/L。与传统的每日三次给药相比，庆大霉素每日一次给药可节省44%的成本。
产后子宫内膜炎女性患者每日一次使用庆大霉素给药可达到治疗性峰浓度且无药物蓄积。该给药方案可大幅节省成本。
