Kosno-Kruszewska E, Wierzba-Bobrowicz T, Szpak G M, Kuran W
Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa.
Folia Neuropathol. 1996;34(4):221-5.
A primary lymphoma in the left temporal lobe of the brain in a 66-year old man is presented. The brain tumor was diagnosed on the basis of clinical symptoms (temporary dizziness, mixed aphasia and right hemiparesis) and repeated CT scanning of the brain. The patient with diagnosed malignant, non-operative brain tumor underwent a series of radiotherapy and steroidtherapy. The patient died twelve months after the first signs and symptoms had occurred. A general autopsy did not reveal any neoplasmatic changes. A macroscopic neuropathological examination showed large tumor's mass in the left temporal lobe which was not separated clearly from its surrounding. A microscopic examination included histopathological (HE, Kanzler-Arendt, Perdrau, PATH, PAS) and immunocytochemical techniques (GFAP, anti-galactocerebroside, LCA, CD45RO, OPD4, CD20). It was found that the examined brain tumor was B-cell malignant lymphoma with the presence of T-cells. Since no changes were revealed in internal organs, the tumor was diagnosed as a primary brain lymphoma.
本文报告了一名66岁男性患者，其左侧颞叶出现原发性淋巴瘤。脑肿瘤是根据临床症状（短暂头晕、混合性失语和右侧偏瘫）以及多次脑部CT扫描诊断出来的。该患者被诊断为恶性、不可手术的脑肿瘤，随后接受了一系列放疗和类固醇治疗。自首次出现症状体征十二个月后，患者死亡。全面尸检未发现任何肿瘤性变化。大体神经病理学检查显示左侧颞叶有巨大肿瘤块，与周围组织分界不清。显微镜检查包括组织病理学（苏木精-伊红染色、坎兹勒-阿伦特染色、佩德劳染色、PATH染色、过碘酸雪夫染色）和免疫细胞化学技术（胶质纤维酸性蛋白、抗半乳糖脑苷脂、白细胞共同抗原、CD45RO、OPD4、CD20）。结果发现，所检查的脑肿瘤为伴有T细胞的B细胞恶性淋巴瘤。由于内脏器官未发现变化，该肿瘤被诊断为原发性脑淋巴瘤。
