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[动脉硬化性脑梗死中各因素间相互作用的分析]

[Analysis on the interaction among agents in arteriosclerotic cerebral infarction].

作者信息

Zhou J Y, Shen J, Shao Y N

机构信息

School of Public Health, Nanjing Medical University.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1997 Oct;18(5):279-81.

PMID:9812489
Abstract

An 1:1 matched case-control study including 105 arteriosclerotic cerebral infarction cases and 105 controls was carried out to estimate the etiologic interaction, in Yi-xing city, March 1997. Results showed that the major risk factors were high levels of serum TG, Lp(a) and BMI while serum level of HDL-C was the only protective factor. When several levels were divided on Lp(a) and BMI, a significantly dose response relation was found. Considering the correlation among serum concentration of lipids, we analysed the interaction of different factors, using Log-Linear models. Results showed that there were significant interactions between arteriosclerotic cerebral infarction and TC, TG, HDL-C and Lp(a). There were also interactions between TC, TG, HDL-C and LDL-C. However, the strongest interaction is expected to happen at what level remains further investigations.

摘要

1997年3月在宜兴市开展了一项1:1匹配的病例对照研究,纳入105例动脉粥样硬化性脑梗死病例和105例对照,以评估病因相互作用。结果显示,主要危险因素为血清甘油三酯(TG)、脂蛋白(a) [Lp(a)]水平升高及体重指数(BMI)升高,而血清高密度脂蛋白胆固醇(HDL-C)水平是唯一的保护因素。按Lp(a)和BMI划分几个水平时,发现存在显著的剂量反应关系。考虑到血脂血清浓度之间的相关性,我们使用对数线性模型分析了不同因素之间的相互作用。结果显示,动脉粥样硬化性脑梗死与总胆固醇(TC)、TG、HDL-C和Lp(a)之间存在显著相互作用。TC、TG、HDL-C和低密度脂蛋白胆固醇(LDL-C)之间也存在相互作用。然而,最强的相互作用预计发生在何种水平仍有待进一步研究。

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