Zhou J Y, Shen J, Shao Y N
School of Public Health, Nanjing Medical University.
Zhonghua Liu Xing Bing Xue Za Zhi. 1997 Oct;18(5):279-81.
An 1:1 matched case-control study including 105 arteriosclerotic cerebral infarction cases and 105 controls was carried out to estimate the etiologic interaction, in Yi-xing city, March 1997. Results showed that the major risk factors were high levels of serum TG, Lp(a) and BMI while serum level of HDL-C was the only protective factor. When several levels were divided on Lp(a) and BMI, a significantly dose response relation was found. Considering the correlation among serum concentration of lipids, we analysed the interaction of different factors, using Log-Linear models. Results showed that there were significant interactions between arteriosclerotic cerebral infarction and TC, TG, HDL-C and Lp(a). There were also interactions between TC, TG, HDL-C and LDL-C. However, the strongest interaction is expected to happen at what level remains further investigations.
1997年3月在宜兴市开展了一项1:1匹配的病例对照研究，纳入105例动脉粥样硬化性脑梗死病例和105例对照，以评估病因相互作用。结果显示，主要危险因素为血清甘油三酯（TG）、脂蛋白(a) [Lp(a)]水平升高及体重指数（BMI）升高，而血清高密度脂蛋白胆固醇（HDL-C）水平是唯一的保护因素。按Lp(a)和BMI划分几个水平时，发现存在显著的剂量反应关系。考虑到血脂血清浓度之间的相关性，我们使用对数线性模型分析了不同因素之间的相互作用。结果显示，动脉粥样硬化性脑梗死与总胆固醇（TC）、TG、HDL-C和Lp(a)之间存在显著相互作用。TC、TG、HDL-C和低密度脂蛋白胆固醇（LDL-C）之间也存在相互作用。然而，最强的相互作用预计发生在何种水平仍有待进一步研究。
