Zhang P, Liang K, Yin C
Department of Digestive Diseases, Shanghai First People's Hospital.
Zhonghua Nei Ke Za Zhi. 1997;36(1):25-7.
The aim of this study is to ascertain whether the formation of nitric oxide is argumented in patients with liver cirrhosis and its mechanism. 38 cirrhotic patients and 15 normal controls were studied. Higher plasma levels of NO2-/NO3- (stable end products of nitric oxide), endotoxin, tumor necrosis factor alpha (TNF alpha) and cyclic guanosine monophosphate (cGMP) were observed in patients with cirrhosis than in normal controls (P < 0.01, 0.01, 0.01, 0.05). The higher Child-Pugh, the higher plasma NO2-/NO3- level. The concentration of NO2-/NO3- had a positive correlation with that of endotoxin and TNF alpha (r = 0.481, P < 0.01; r = 0.351, P < 0.05). It is suggested that the production of nitric oxide is augmented and could be induced by endotoxin and TNF alpha. Execessive formation of nitric oxide may be related to hyperdynamic circulation in cirrhosis.
本研究旨在确定肝硬化患者体内一氧化氮的生成是否增加及其机制。研究了38例肝硬化患者和15例正常对照。与正常对照相比，肝硬化患者血浆中一氧化氮的稳定终产物NO2-/NO3-、内毒素、肿瘤坏死因子α（TNFα）和环磷酸鸟苷（cGMP）水平更高（P<0.01、0.01、0.01、0.05）。Child-Pugh分级越高，血浆NO2-/NO3-水平越高。NO2-/NO3-浓度与内毒素和TNFα浓度呈正相关（r=0.481，P<0.01；r=0.351，P<0.05）。提示肝硬化患者体内一氧化氮生成增加，且可能由内毒素和TNFα诱导。一氧化氮的过度生成可能与肝硬化的高动力循环有关。
