Zhuang L, Ma Z, Liu T
Gastroenterology department of the first hospital affiliated to Harbin Medical University. Harbin 150001, China.
Zhonghua Gan Zang Bing Za Zhi. 2000 Apr;8(2):94-5.
To study the anti-endotoxin therapy on the plasma levels of nitric oxide, prostacyclin, tumor necrosis factor-alpha in patients with liver cirrhosis after hepatitis.
Thirty patients with decompensated liver cirrhosis accepted anti-endotoxin therapy with oral Amoxycillin and Smedta for 2 weeks. Plasma levels of endotoxin, nitric oxide, prostacyclin and tumor necrosis factor-alpha were detected before and after therapy in study group and control group, respectively. The relationship between endotoxin and vasoactive substances and between the four substances and the status of patients were analyzed.
The four substances were all increased significantly (P<0.01) in patients with liver cirrhosis compared with control group and decreased obviously after treatment for 2 weeks (endotoxin from 0.546X10(21) U/L to 0. 347X10(21) U/L, no from 56.498 mumol/L to 31.256 mumol/L, 6-keto-PGF1 alpha from 716.964 ng/L to 539.867ng/L, and TNF-alpha from 3.090 mug/L to 1.750 mug/L (P<0.01).
The plasma levels of nitric oxide, prostacyclin and tumor necrosis factor-alpha increased because of endotoxemia. Amoxycillin and Smecta can clear endotoxin out effectively.
研究抗内毒素疗法对肝炎后肝硬化患者血浆一氧化氮、前列环素、肿瘤坏死因子-α水平的影响。
30例失代偿期肝硬化患者接受口服阿莫西林和思密达抗内毒素治疗2周。分别检测研究组和对照组治疗前后血浆内毒素、一氧化氮、前列环素和肿瘤坏死因子-α水平。分析内毒素与血管活性物质之间以及这四种物质与患者病情之间的关系。
与对照组相比，肝硬化患者这四种物质均显著升高（P<0.01），治疗2周后明显下降（内毒素从0.546×10(21)U/L降至0.347×10(21)U/L，一氧化氮从56.498μmol/L降至31.256μmol/L，6-酮-前列腺素F1α从716.964ng/L降至539.867ng/L，肿瘤坏死因子-α从3.090μg/L降至1.750μg/L，P<0.01）。
内毒素血症导致血浆一氧化氮、前列环素和肿瘤坏死因子-α水平升高。阿莫西林和思密达能有效清除内毒素。
