[A follow-up study on correlated factors for intrauterine infection of hepatitis B virus].

One hundred and twenty-two pregnant women with positive serum hepatitis B surface antigen (HBsAg) and their infants were followed-up to study the risk factors related to intrauterine infection of hepatitis B virus (HBV). Infants were immunized with three doses of hepatitis B vaccine within 24 hours after birth, one month and six months of age, respectively, and hepatitis B immunoglobulin (HBIG) was injected simultaneously with the first dose. Markers of HBV infection in pregnant women and infants were detected by enzyme linked immunosorbent assay (ELISA). Results showed that 13 infants were detected positive for HBsAg in their sera, eight of them were positive at their birth and the other five converted positive during follow-up. Simple and multiple logistic regression analyses showed that positivity of hepatitis Be antigen (HBeAg) in mothers and their threatened abortion related to intrauterine infection, with relative risks of 31.27 and 10.87, respectively.