促甲状腺素释放激素对精神分裂症的行为影响。

Behavioral effects of protirelin in schizophrenia.

作者信息

Inanaga K, Nakano T, Nagata T, Tanaka M, Ogawa N

出版信息

Arch Gen Psychiatry. 1978 Aug;35(8):1011-4. doi: 10.1001/archpsyc.1978.01770320105010.

DOI:10.1001/archpsyc.1978.01770320105010

Abstract

The effects of protirelin were compared with those of placebo in a multi-institutional, double-blind, controlled study of 143 chronic schizophrenic patients. Treatment with neuroleptics was continued during the study and 4 mg protirelin per day was orally administered for 14 days. Protirelin appeared to be significantly superior to placebo on the physicians' global ratings of efficacy. Increased motivation for work was isolated as a target effect but such symptoms as facial expression, emotional rapport, and psychomotor activity also appeared to be improved by addition of protirelin to the neuroleptics. Onset of the therapeutic effect of protirelin occurred within a week of medication in most of the patients who showed improvement. No adverse reactions were encountered.

摘要

在一项针对143名慢性精神分裂症患者的多机构、双盲、对照研究中，对促甲状腺素释放激素（TRH）与安慰剂的效果进行了比较。研究期间继续使用抗精神病药物治疗，每天口服4毫克促甲状腺素释放激素，持续14天。在医生对疗效的整体评分上，促甲状腺素释放激素似乎显著优于安慰剂。工作动力增强被确定为一个目标效应，但在抗精神病药物中添加促甲状腺素释放激素后，诸如面部表情、情感融洽度和精神运动活动等症状似乎也有所改善。在大多数有改善的患者中，促甲状腺素释放激素的治疗效果在用药一周内就出现了。未出现不良反应。