Braun R E
Department of Genetics, University of Washington, 1959 NE Pacific, Seattle, WA, 98195, USA.
Semin Cell Dev Biol. 1998 Aug;9(4):483-9. doi: 10.1006/scdb.1998.0226.
The synthesis and storage of mRNAs prior to their translation is a necessity during spermatogenesis as global transcription ceases several days prior to the completion of spermatid differentiation. Post-transcriptional control can be mediated by sequences in the 5' and 3' untranslated regions of mRNAs, and in some cases separate elements may regulate translational repression and translational activation. Translational repression is essential for spermatid differentiation as premature translation can lead to an arrest in spermatid differentiation and cause dominant male sterility.
在精子发生过程中，mRNA在翻译之前进行合成和储存是必要的，因为在精子细胞分化完成前几天，整体转录就停止了。转录后调控可由mRNA的5'和3'非翻译区中的序列介导，在某些情况下，不同元件可能分别调节翻译抑制和翻译激活。翻译抑制对于精子细胞分化至关重要，因为过早翻译会导致精子细胞分化停滞并引起显性雄性不育。
