Tex13a优化精子活力：其在mRNA周转中的潜在作用

Li Yinchuan, Mi Panpan, Chen Xue, Wu Jiabao, Liu Xiaohua, Tang Yunge, Cheng Jinmei, Huang Yingying, Qin Weibing, Cheng C Yan, Sun Fei

Institute of Reproductive Medicine, Medical School of Nantong University, Nantong, China.

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou, China.

Front Cell Dev Biol. 2021 Oct 18;9:761627. doi: 10.3389/fcell.2021.761627. eCollection 2021.

mRNAs have been found to undergo substantial selective degradation during the late stages of spermiogenesis. However, the mechanisms regulating this biological process are unknown. In this report, we have identified , a spermatid-specific gene that interacts with the CCR4-NOT complex and is implicated in the targeted degradation of mRNAs encoding particular structural components of sperm. Deletion of led to a delayed decay of these mRNAs, lowered the levels of house-keeping genes, and ultimately lowered several key parameters associated with the control of sperm motility, such as the path velocity (VAP, average path velocity), track speed (VCL, velocity curvilinear), and rapid progression.

已发现mRNA在精子发生后期会经历大量选择性降解。然而，调节这一生物学过程的机制尚不清楚。在本报告中，我们鉴定出了一个精子细胞特异性基因，它与CCR4-NOT复合体相互作用，并参与了编码精子特定结构成分的mRNA的靶向降解。该基因的缺失导致这些mRNA的降解延迟，降低了管家基因的水平，并最终降低了与精子运动控制相关的几个关键参数，如路径速度（VAP，平均路径速度）、轨迹速度（VCL，曲线速度）和快速前进能力。