Schilkrut R, Rüther E, Ackenheil M, Eben E, Hippius H
Pharmakopsychiatr Neuropsychopharmakol. 1976 Jan;9(1):43-7. doi: 10.1055/s-0028-1094477.
Palmomental reflex, glabellar reflex and oral responses were studied in the course of a treatment with Haloperidol in 14 psychotic patients with a chronic organic brain damage. An increase of the three responses was found; maximum intensity and frequency of the primitive reflexes were reached during the first 5 days of treatment. There was no correlation found between the intensity of primitive reflexes and changes of psychopathological symptoms, of extrapyramidal scores and of homovanillic acid (=HVA) and 5-hydroxyindoleacetic acid (5=5-HIAA) concentration in cerebrospinal fluid (=CSF). The presence of primitive responses is interpreted as a "decompensation phenomenon" induced by neuroleptics, probably in relation to an effect on the central nervous system (=CNS) dopamine receptors. It is suggested that the appearance of several definite, primitive reflexes during neuroleptic therapy may have some diagnostic and prognostic significance.
对14例患有慢性器质性脑损伤的精神病患者在使用氟哌啶醇治疗过程中进行了掌颏反射、眉间反射和口部反应的研究。发现这三种反应均增强；原始反射的最大强度和频率在治疗的前5天达到。未发现原始反射强度与精神病理症状变化、锥体外系评分以及脑脊液（=CSF）中高香草酸（=HVA）和5-羟吲哚乙酸（5=5-HIAA）浓度之间存在相关性。原始反应的出现被解释为抗精神病药物引起的“失代偿现象”，可能与对中枢神经系统（=CNS）多巴胺受体的作用有关。提示在抗精神病药物治疗期间出现几种明确的原始反射可能具有一定的诊断和预后意义。
