Schreiber A, Eulenberger K, Bauer K
Zoologisches Institut, Universität Heidelberg, Germany.
Exp Clin Immunogenet. 1998;15(3):154-70. doi: 10.1159/000019067.
Thirty-seven antigenic determinants were identified in the albumins, the immunoglobulin micro- and IgG(Fc) chains, and the C3 proteins of 51 carnivoran (sub)species from 31 genera, and in 12 noncarnivoran mammals. In addition to 19 determinants plesiomorphic for Carnivora as an order, 18 synapomorphic epitopes of carnivoran families revealed nine phylogenetic reaction groups: (1) canids, (2) ursids, (3) the racoon, (4) the Weddell seal, (5) the lesser panda, (6) the harbour seal, (7) mustelids, (8) viverrids and hyaenas, and (9) felids. These data identify Canoidea (Canidae, Ursidae, Phocidae, Procyonidae, Ailuridae, Mustelidae) and Feloidea (Viverridae, Hyaenidae, Felidae) as two fundamentally differentiated lineages of Carnivora, and confirm the inclusion of seals among the former. The Ursidae are the sister group of the Canidae. The antigenic determinants in the studied proteins do not subdivide the Canidae, Ursidae and Felidae into immunologically differentiated lineages.
在来自31个属的51种食肉目（亚）物种以及12种非食肉目哺乳动物的白蛋白、免疫球蛋白微链和IgG（Fc）链以及C3蛋白中，鉴定出了37个抗原决定簇。除了19个对食肉目作为一个目来说是近裔共性的决定簇外，食肉目各科的18个共有衍征表位揭示了9个系统发育反应组：（1）犬科，（2）熊科，（3）浣熊，（4）威德尔海豹，（5）小熊猫，（6）港海豹，（7）鼬科，（8）灵猫科和鬣狗科，以及（9）猫科。这些数据将犬型总科（犬科、熊科、海豹科、浣熊科、小熊猫科、鼬科）和猫型总科（灵猫科、鬣狗科、猫科）确定为食肉目的两个根本不同的谱系，并证实海豹属于前者。熊科是犬科的姐妹群。所研究蛋白质中的抗原决定簇并没有将犬科、熊科和猫科细分为免疫分化的谱系。
