Waitzberg D L, Mester M
University of São Paulo School of Medicine, SP, Brazil.
Arq Gastroenterol. 1998 Apr-Jun;35(2):110-5.
Considerable progress has been made during the last decade in the understanding of the pathophysiology of sepsis and multiple organ dysfunction syndrome. Gut-derived sepsis has been recognized as an important etiology of multiple organ dysfunction syndrome. Bacterial translocation of indigenous intestinal flora to the systemic circulation has been postulated as an important etiology of gut-derived sepsis. In this paper, we review the fundamental aspects of bacterial translocation as mechanism of disease, and the influence of nutritional support. Critical animal and human data are presented and discussed, and emphasis is given to its potential clinical applications.
在过去十年中，人们对脓毒症和多器官功能障碍综合征的病理生理学的理解取得了相当大的进展。肠道源性脓毒症已被公认为是多器官功能障碍综合征的一个重要病因。肠道内源性菌群向体循环的细菌移位被认为是肠道源性脓毒症的一个重要病因。在本文中，我们回顾了作为疾病机制的细菌移位的基本方面以及营养支持的影响。文中展示并讨论了关键的动物和人体数据，并强调了其潜在的临床应用。
