Hutter H, Hammer A, Dohr G, Hunt J S
Department of Histology and Embryology, University of Graz, Austria.
Dev Immunol. 1998;6(3-4):197-204. doi: 10.1155/1998/65065.
Pregnancy in the human presents an "immunological paradox," because of the unexpected willingness of mothers to accept genetically disparate tissues. The fact that the fetus can develop unharmed for nine months shows that protective mechanisms must exist to permit its survival. The conditions that permit the genetically dissimilar human fetus to evade rejection by its mother's immune system have been the subject of intense interest for several decades. As the placental cells, which are in contact with maternal blood or tissue, are devoid of HLA class II antigens, interest has focused on the expression of HLA class I molecules. Recent developments in the constitutive, transcriptional, and translational expression of HLA class I molecules on anatomically and morphologically different subpopulations of trophoblast cells will form the basis of this short review.
人类怀孕呈现出一种“免疫悖论”，因为母亲愿意意外地接受基因不同的组织。胎儿能够在九个月内安然无恙地发育，这一事实表明必然存在保护机制以确保其存活。几十年来，允许基因不同的人类胎儿逃避母亲免疫系统排斥的条件一直是人们密切关注的课题。由于与母体血液或组织接触的胎盘细胞缺乏HLA II类抗原，人们的兴趣集中在了HLA I类分子的表达上。滋养层细胞在解剖学和形态学上不同亚群上HLA I类分子的组成性、转录性和翻译性表达的最新进展将构成这篇简短综述的基础。
