Gharavi A E, Pierangeli S S
Morehouse School of Medicine, Department of Medicine, Atlanta, GA 30310-1495, USA.
Lupus. 1998;7 Suppl 2:S52-4. doi: 10.1177/096120339800700213.
The clinical associations of antiphospholipid antibodies (aPL) are well recognized but the mechanism(s) causing the production of these antibodies are not yet known. We demonstrated the induction of pathogenic aPL antibodies that caused intrauterine fetal death and transverse myelopathy due to spinal cord infarction in mice by immunization with foreign beta2GPI. We also induced aPL and anti-beta2-GPI in mice by immunization with PL-binding viral peptides and hypothesized that in APS patients, aPL may be induced by beta2GPI-like-PL-binding products of common human bacteria and viruses.
抗磷脂抗体（aPL）的临床关联已得到充分认识，但其产生机制尚不清楚。我们通过用外源β2GPI免疫小鼠，证明了致病性aPL抗体的诱导，这些抗体导致小鼠宫内胎儿死亡和脊髓梗死所致的横贯性脊髓病。我们还用结合磷脂的病毒肽免疫小鼠诱导出了aPL和抗β2-GPI，并推测在抗磷脂综合征（APS）患者中，aPL可能由常见人类细菌和病毒的β2GPI样磷脂结合产物诱导产生。
