Ferrier C M, van Muijen G N, Ruiter D J
Department of Pathology, University Hospital Nijmegen, The Netherlands.
Ann Med. 1998 Oct;30(5):431-42. doi: 10.3109/07853899809002484.
From a great number of studies there is clear evidence that several extracellular proteolytic enzymes play an important role in various tumour-related processes. This review focusses on proteases in cutaneous melanoma. The current knowledge on and insights into the involvement of proteases in tumour progression are based on in vitro studies, on animal model studies and on investigations using patient material. In the field of melanoma, these three modalities are also applied to the investigation on the impact of proteases. Consequently, the current review summarizes research on both human melanoma cell lines and human melanocytic lesions. In addition, results obtained from animal experiments are included.
大量研究有明确证据表明，几种细胞外蛋白水解酶在各种肿瘤相关过程中发挥重要作用。本综述聚焦于皮肤黑色素瘤中的蛋白酶。目前关于蛋白酶参与肿瘤进展的知识和见解基于体外研究、动物模型研究以及使用患者材料的调查。在黑色素瘤领域，这三种方式也应用于蛋白酶影响的研究。因此，本综述总结了关于人类黑色素瘤细胞系和人类黑素细胞病变的研究。此外，还纳入了动物实验获得的结果。
