Gubareva L V, McCullers J A, Bethell R C, Webster R G
Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
J Infect Dis. 1998 Dec;178(6):1592-6. doi: 10.1086/314515.
A recent outbreak of influenza in Hong Kong was caused by a highly virulent virus of avian origin. Concern that the appearance of such a virus in the human population may be a harbinger of a new pandemic has brought increased attention to the issue of antivirals available for treatment of influenza. A/HongKong/156/97 (H5N1), the first virus of H5N1 subtype isolated from a human host, is highly virulent in the mouse model and can infect mouse lungs without requiring adaptation. High mortality and evidence of systemic disease, including spread to the brain after intranasal inoculation, are observed. Zanamivir, a novel neuraminidase inhibitor, is effective at decreasing replication of the virus in vitro. In a model of lethal challenge in mice, zanamivir reduces lung titers of the virus and decreases morbidity and mortality.
香港近期爆发的流感是由一种高致病性的禽源病毒引起的。人们担心这种病毒在人群中出现可能是新的大流行的先兆，这使得对可用于治疗流感的抗病毒药物问题的关注度有所提高。A/香港/156/97（H5N1）是从人类宿主中分离出的第一株H5N1亚型病毒，在小鼠模型中具有高致病性，无需适应就能感染小鼠肺部。观察到高死亡率以及包括经鼻接种后扩散至脑部在内的全身性疾病迹象。扎那米韦是一种新型神经氨酸酶抑制剂，在体外能有效减少病毒复制。在小鼠致死性攻击模型中，扎那米韦可降低病毒在肺部的滴度，并降低发病率和死亡率。
