Di Renzo M F, Olivero M, Giacomini A, Porte H, Chastre E, Mirossay L, Nordlinger B, Bretti S, Bottardi S, Giordano S
Department of Biomedical Science and Oncology, University of Torino Medical School, Torino, Institute of Histology, University of Sassari Medical School, Sassari, Italy.
Clin Cancer Res. 1995 Feb;1(2):147-54.
The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter factor, a potent mitogen for epithelial cells that also promotes cell motility and invasiveness. We have studied the changes of c-met gene expression that occur during the progression of colorectal tumors. Sixteen adenomas, 123 primitive carcinomas, and 25 liver metastases were examined. In several instances it was possible to compare same-patient samples of normal colon mucosa against primary tumor and primary carcinoma against synchronous metastasis. The expression of the c-met gene was increased from 5- to 50-fold in about 50% of tumors, at any stage of progression, and in 70% of liver metastases. Overexpression was associated with amplification of the c-met gene in only 10% of carcinomas, but in 8 of 9 metastases examined. These data suggest that overexpression of the c-met oncogene contributes a selective growth advantage to neoplastic colorectal cells at any stage of tumor progression. Moreover, amplification appears to give a further selective advantage for the acquisition of metastatic potential.
c-met癌基因编码肝细胞生长因子/分散因子的受体，肝细胞生长因子/分散因子是一种对上皮细胞有强大作用的促分裂原，它还能促进细胞运动和侵袭。我们研究了结直肠癌进展过程中c-met基因表达的变化。检测了16个腺瘤、123个原发性癌和25个肝转移瘤。在一些情况下，可以将同一患者的正常结肠黏膜样本与原发性肿瘤进行比较，以及将原发性癌与同步转移瘤进行比较。在进展的任何阶段，约50%的肿瘤以及70%的肝转移瘤中，c-met基因的表达增加了5至50倍。在仅10%的癌中，过表达与c-met基因扩增相关，但在检测的9个转移瘤中有8个如此。这些数据表明，c-met癌基因的过表达在肿瘤进展的任何阶段都赋予肿瘤性结肠直肠细胞选择性生长优势。此外，扩增似乎为获得转移潜能提供了进一步的选择性优势。
