Morrow P E, Kilpper R W, Beiter H E, Gibb F R
Radiology. 1976 Nov;121(2):415-21. doi: 10.1148/121.2.415.
Studies of pylmonary clearance of tantalum dust labeled with 182Ta in dogs have been extended to as far as 816 days postexposure in order to substantiate earlier pulmonary retention data, examine lymphatic uptake, and seek long-term pathological changes. Exposure to 5-mug and 10-mug powders was compared with the results of earlier 1-mug studies. The 2.1-year long-term clearance half-time of 1-mug powder was confirmed, while the 5-mug and 10-mug powders were found to have a mean long-term retention half-time of 333 days. All three particle sizes demonstrated rapid postinsufflation uptake by the pulmonary lymph nodes, followed by either retention or very slow clearance. No tantalum-induced pathological changes were found on histological examination.
对用182Ta标记的钽粉尘在犬肺部清除情况的研究已延长至暴露后816天，以证实早期肺部潴留数据、检查淋巴摄取情况并寻找长期病理变化。将暴露于5微克和10微克粉末的结果与早期1微克研究的结果进行了比较。证实了1微克粉末的2.1年长时清除半衰期，而5微克和10微克粉末的平均长时潴留半衰期为333天。所有三种粒径的颗粒在吹入后均迅速被肺淋巴结摄取，随后要么潴留，要么清除非常缓慢。组织学检查未发现钽引起的病理变化。
