Tanno S, Obara T, Sohma M, Tanaka T, Izawa T, Fujii T, Nishino N, Ura H, Kohgo Y
Third Department of Internal Medicine, Asahikawa Medical College, Japan.
Int J Pancreatol. 1998 Oct;24(2):129-32. doi: 10.1007/BF02788571.
Serous cystadenoma of the pancreas is usually unifocal; multifocal tumors are rare. We report a case of multifocal serous cystadenoma of the pancreas in a 48-yr-old female complaining of general malaise. Serum tumor markers, such as CA 19-9, DUPAN-2, and Span-1, were elevated. Abdominal ultrasound (US) and computed tomography (CT) scans revealed two distinct cystic masses in the head and body of the pancreas, respectively. The patient underwent total pancreatectomy. The resected pancreas contained two discrete cystic masses in the head and body; no solid components were observed. Microscopically, the inner surfaces of the cysts were evenly lined by a single layer of low cuboidal or significantly attenuated epithelial cells containing clear cytoplasm and abundant glycogen without other morphological alterations. The histogenesis of serous cystadenoma is not clear; multicentric tumors may be helpful in understanding histogenesis.
胰腺浆液性囊腺瘤通常为单灶性；多灶性肿瘤罕见。我们报告一例48岁女性胰腺多灶性浆液性囊腺瘤病例，该患者主诉全身不适。血清肿瘤标志物如CA 19-9、DUPAN-2和Span-1升高。腹部超声（US）和计算机断层扫描（CT）显示胰腺头部和体部分别有两个不同的囊性肿块。患者接受了全胰切除术。切除的胰腺在头部和体部包含两个离散的囊性肿块；未观察到实性成分。显微镜下，囊肿内表面均匀地衬有单层低立方上皮细胞或显著变薄的上皮细胞，这些细胞含有透明的细胞质和丰富的糖原，无其他形态学改变。浆液性囊腺瘤的组织发生尚不清楚；多中心性肿瘤可能有助于理解其组织发生。
