Soria J C, Theodore C, Gerbaulet A
Département de médecine, Institut Gustave-Roussy, Villejuif.
Bull Cancer. 1998 Sep;85(9):773-84.
Squamous cell carcinoma is the most common tumour of the penis. It is a rare disease in Western countries, and occurs in patients after the sixth decade. The pattern of spread is loco-regional, and prognosis is poor when nodal metastases appear. The etiology of penis cancer is discussed, however human papillomavirus infection, tobacco, poor hygiene and phimosis are often associated with this disease. Radical surgery gives the best control of the primary tumour, but it is mutilating. Conservative therapies (laser, radiotherapy, and particularly brachytherapy...) are an attracting option. Regional lymph nodes management is extremely controversial. Lymph node metastases, invasion of corpus cavernosum, and poor differentiation are pejorative prognostic factors. More than half patients are responsive to modern polychemotherapy combinations. However responses are transient and chemotherapy alone is not curative for metastatic disease. Etiologic factors, clinical presentation, staging work-up requirements, prognostic factors and therapeutic modalities are detailed.
鳞状细胞癌是阴茎最常见的肿瘤。在西方国家，这是一种罕见疾病，多发生于60岁以后的患者。其扩散方式为局部区域性，出现淋巴结转移时预后较差。本文讨论了阴茎癌的病因，然而人乳头瘤病毒感染、烟草、卫生条件差和包茎常与该病相关。根治性手术能最佳地控制原发肿瘤，但具有致残性。保守治疗（激光、放疗，尤其是近距离放疗……）是一个有吸引力的选择。区域淋巴结的处理极具争议性。淋巴结转移、海绵体侵犯和低分化是不良预后因素。超过半数的患者对现代联合化疗方案有反应。然而，反应是短暂的，单纯化疗对转移性疾病无法治愈。文中详细阐述了病因、临床表现、分期检查要求、预后因素和治疗方式。
