Kao C H, ChangLai S P, Chieng P U, Yen R F, Yen T C
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
J Clin Oncol. 1998 Nov;16(11):3550-5. doi: 10.1200/JCO.1998.16.11.3550.
The effectiveness of positron emission tomography (PET) with 1 8-fluoro-2-deoxyglucose (FDG) for detecting suspected recurrence of nasopharyngeal carcinomas (NPC) was evaluated and compared with computed tomography (CT).
FDG-PET studies were performed on 36 NPC patients 4 months after radiotherapy. The images were interpreted visually and quantitatively by calculating standardized uptake values (SUVs).
The sensitivity, specificity, and accuracy of visually interpreted FDG-PET images, for differentiation of recurrent or persistent NPC from benign lesions, were 100%, 96%, and 97%, respectively. Cases with recurrent or persistent NPC (1.6 to 5.8) had significantly higher SUVs than cases with benign lesions (0.8 to 1.5). The sensitivity, specificity, and accuracy of CT for detecting recurrent or persistent NPC were 72%, 88%, and 83%, respectively.
FDG-PET is a better tool than CT for the detection of recurrent or persistent NPC. Either visual interpretation or SUV can be used to differentiate benign lesions from recurrent or persistent NPC.
评估正电子发射断层扫描（PET）联合18-氟-2-脱氧葡萄糖（FDG）检测鼻咽癌（NPC）疑似复发的有效性，并与计算机断层扫描（CT）进行比较。
对36例NPC患者放疗4个月后进行FDG-PET检查。通过计算标准化摄取值（SUV）对图像进行视觉和定量分析。
FDG-PET图像对复发性或持续性NPC与良性病变鉴别的敏感度、特异度和准确度分别为100%、96%和97%。复发性或持续性NPC患者的SUV（1.6至5.8）显著高于良性病变患者（0.8至1.5）。CT检测复发性或持续性NPC的敏感度、特异度和准确度分别为72%、88%和83%。
对于复发性或持续性NPC的检测，FDG-PET是比CT更好的工具。视觉分析或SUV均可用于区分良性病变与复发性或持续性NPC。
