Yu-Lee L, Luo G, Moutoussamy S, Finidori J
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Cell Mol Life Sci. 1998 Oct;54(10):1067-75. doi: 10.1007/s000180050235.
The peptide hormones, prolactin (PRL) and growth hormone (GH), are known to regulate numerous target tissues. Among such targets are cells of the immune system, including T cells, B cells, macrophages and natural killer cells. We have cloned a panel of PRL- and GH-inducible T cell genes for use in studies to understand how these hormones through the expression of these genes modulate the biology of immune function cells. This article focuses on the signalling pathways emanating from the PRL receptor (PRL-R) and GH receptor (GH-R), and the expression of PRL-inducible target genes.
已知肽类激素催乳素（PRL）和生长激素（GH）可调节众多靶组织。免疫系统的细胞，包括T细胞、B细胞、巨噬细胞和自然杀伤细胞，就是这类靶组织。我们已经克隆了一组PRL和GH诱导的T细胞基因，用于研究这些激素如何通过这些基因的表达来调节免疫功能细胞的生物学特性。本文重点关注源自催乳素受体（PRL-R）和生长激素受体（GH-R）的信号通路，以及PRL诱导的靶基因的表达。
