Ciesielski A, Nagel P, Lanser K, Sill V
Res Exp Med (Berl). 1976 Jul 22;168(1):35-44. doi: 10.1007/BF01851731.
The influence of Dopamine on microcirculation during hemorrhagic shock was investigated by means of the pancreas chamber technique (HEISIG, 1967). Parameter of microcirculation was the corpuscular flow velocity measured with the "flying spot" method. Simultaneously arterial and venous blood pressure, heart rate, blood gases and pH-status were registered. While a Dopamine-dosage of 5 mug/kg/min did not markedly effect perfusion of the pancreas, application of 10 as well as 20 mug/kg/min Dopamine caused a significant improvement of microcirculation. There was no difference between 10 and 20 mug/kg/min Dopamine. The increase of capillary perfusion can certainly not be explained by the small rise of blood pressure that was found under treatment with Dopamine. The results support the statement of the existence of Dopamine-specific receptors in pancreatic vessels. Compared to a group of animals treated with 5 mug/kg/min Dopamine and an untreated control group, survival rate of animals treated with 10 as well as 20 mug/kg/min Dopamine was significantly increased.
采用胰腺小室技术（海西格，1967年）研究了多巴胺在失血性休克期间对微循环的影响。微循环参数是用“飞点”法测量的血细胞流速。同时记录动脉和静脉血压、心率、血气和pH值状态。当多巴胺剂量为5微克/千克/分钟时，对胰腺灌注没有明显影响，而应用10微克/千克/分钟和20微克/千克/分钟的多巴胺可显著改善微循环。10微克/千克/分钟和20微克/千克/分钟的多巴胺之间没有差异。多巴胺治疗时发现的血压小幅升高肯定无法解释毛细血管灌注的增加。这些结果支持胰腺血管中存在多巴胺特异性受体的说法。与接受5微克/千克/分钟多巴胺治疗的一组动物和未治疗的对照组相比，接受10微克/千克/分钟和20微克/千克/分钟多巴胺治疗的动物存活率显著提高。
