Adams C L, Nelson W J
Cytokinetics, Inc., South San Francisco, CA 94040, USA.
Curr Opin Cell Biol. 1998 Oct;10(5):572-7. doi: 10.1016/s0955-0674(98)80031-8.
Cadherin-mediated adhesion regulates transitions from initial cell-cell recognition to loosely adherent cell clusters and ultimately, to strongly compacted groups of cells in colonies. Recent studies have described distinct roles for intermolecular clustering of cadherins as well as interactions of cadherin with the actin cytoskeleton in establishing cell-cell adhesion. Integrating cytomechanical roles of cadherin-mediated adhesion will lead to a greater understanding of how cadherins regulate tissue morphogenesis.
钙黏蛋白介导的黏附作用调控着从最初的细胞间识别到松散黏附的细胞簇，最终到菌落中紧密压实的细胞群的转变。最近的研究描述了钙黏蛋白分子间聚集以及钙黏蛋白与肌动蛋白细胞骨架相互作用在建立细胞间黏附中的不同作用。整合钙黏蛋白介导黏附的细胞力学作用将有助于更深入地理解钙黏蛋白如何调节组织形态发生。
