Ben-Ze'ev A, Geiger B
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Curr Opin Cell Biol. 1998 Oct;10(5):629-39. doi: 10.1016/s0955-0674(98)80039-2.
Plakoglobin and beta-catenin are homologous proteins functioning in cell adhesion and transactivation. Their activities are controlled by three types of interactions: those with cadherins in adherens junctions, linking them to the actin cytoskeleton; interactions in the nucleus, where they bind to transcription factors and stimulate gene expression; interactions of free cytoplasmic beta-catenin with axin and adenomatous polyposis coli (APC) protein which target it for degradation. Studies in the past year have demonstrated the complex interplay between these three types of interactions and the different behavior of beta-catenin and plakoglobin in their involvement in morphogenesis and tumorigenesis strongly suggesting that catenins play key roles in adhesion-mediated signaling.
桥粒芯蛋白和β-连环蛋白是在细胞黏附和反式激活中发挥作用的同源蛋白。它们的活性受三种相互作用控制：与黏着连接中的钙黏着蛋白相互作用，将它们与肌动蛋白细胞骨架相连；在细胞核中的相互作用，它们在细胞核中与转录因子结合并刺激基因表达；游离细胞质β-连环蛋白与轴蛋白和腺瘤性息肉病大肠杆菌（APC）蛋白的相互作用，这些蛋白将其作为降解靶点。过去一年的研究表明，这三种相互作用之间存在复杂的相互作用，β-连环蛋白和桥粒芯蛋白在参与形态发生和肿瘤发生中的不同行为强烈表明，连环蛋白在黏附介导的信号传导中起关键作用。
