Danek A N, Bryant R G
Chemistry Department, University of Virginia, Charlottesville, USA.
Invest Radiol. 1998 Nov;33(11):773-8. doi: 10.1097/00004424-199811000-00001.
The effects of magnetic relaxation agents are explored in the context of magnetization transfer pulse sequences using cross-linked protein gels as modeled tissue systems.
Magnetization transfer pulse sequences were used to study contrast agents that are designed to bind to rotationally immobilized protein targets.
The dynamic range available from contrast agents, used in conjunction with magnetization transfer pulse sequences, is comparable with or better than that based on spin-echo imaging sequences with short repetition times. Furthermore, useful changes in the intensity of water resonances may be achieved by using this combined approach even though the paramagnetic metal center may not have a free coordination position in the chelate complex for water molecule exchange.
The inclusion of magnetization transfer acquisition protocols in the context of magnetic imaging with contrast agents presents new opportunities for control of the information content of the image and for new classes of contrast agent structure and delivery.
以交联蛋白凝胶作为模拟组织系统，在磁化传递脉冲序列的背景下探究磁弛豫剂的作用。
使用磁化传递脉冲序列研究旨在与旋转固定的蛋白质靶点结合的造影剂。
与磁化传递脉冲序列联合使用的造影剂的动态范围，与基于短重复时间自旋回波成像序列的动态范围相当或更好。此外，即使顺磁性金属中心在螯合物中可能没有用于水分子交换的自由配位位置，通过使用这种联合方法也可以实现水共振强度的有效变化。
在使用造影剂的磁成像中纳入磁化传递采集协议，为控制图像信息内容以及新型造影剂结构和递送提供了新机会。
