Krueger R R, Marchi V, Gualano A, Juhasz T, Speaker M, Suárez C
Saint Louis University Eye Institute, Missouri 63104, USA.
J Cataract Refract Surg. 1998 Nov;24(11):1434-40. doi: 10.1016/s0886-3350(98)80163-6.
To evaluate the use of a picosecond neodymium:YLF (Nd:YLF) laser as a nonmechanical intrastromal microkeratome.
Universita Cattolica del Sacro Cuore, Rome, Italy.
An intrastromal spiral disc pattern of picosecond laser pulses was used to create a corneal flap for laser in situ keratomileusis (LASIK) in 14 partially sighted eyes.
Flaps with a 6.0 mm diameter and 180 to 200 microns depth were successfully created in most cases. The underlying stroma was treated with a Lambda Physik excimer laser using a 3.5 to 4.5 mm optical zone. Patients were divided into 3 groups for target corrections of 5.0, 10.0, and 15.0 diopters of myopia. Good corneal clarity and refractive undercorrection were recorded in each group 6 months postoperatively. The undercorrection was due in part to the limited optical zone of the laser's delivery system. Some flap decentration was noted.
This pilot study indicates that the Nd:YLF picosecond laser may be clinically applied for creating corneal flaps for LASIK. Further refinements of the laser delivery system will include enlargement of the flap diameter and improvements in flap centration. The use of a femtosecond laser may expand the capabilities and precision of this technology.
评估皮秒钕：钇锂氟化物（Nd:YLF）激光作为非机械性基质内微型角膜刀的应用。
意大利罗马圣心天主教大学。
在14只视力部分受损的眼睛中，使用皮秒激光脉冲的基质内螺旋盘状模式为准分子原位角膜磨镶术（LASIK）制作角膜瓣。
在大多数情况下成功制作出直径6.0毫米、深度180至200微米的角膜瓣。使用Lambda Physik准分子激光对3.5至4.5毫米的光学区的基质下层进行治疗。将患者分为三组，分别进行5.0、10.0和15.0屈光度近视的目标矫正。术后6个月，每组均记录到良好的角膜清晰度和屈光欠矫。屈光欠矫部分归因于激光传输系统有限的光学区。观察到一些角膜瓣偏心。
这项初步研究表明，Nd:YLF皮秒激光可临床应用于为LASIK制作角膜瓣。激光传输系统的进一步改进将包括扩大角膜瓣直径和改善角膜瓣中心定位。飞秒激光的使用可能会扩展这项技术的能力和精度。
