Grossman Z, Feinberg M, Kuznetsov V, Dimitrov D, Paul W
NIH Office of AIDS Research, Bethesda, MD 20892, USA.
Immunol Today. 1998 Nov;19(11):528-32. doi: 10.1016/s0167-5699(98)01353-x.
The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs.
据推测，接受抗逆转录病毒药物治疗的患者血浆中HIV RNA的下降速率反映了先前被HIV感染细胞的半衰期。在此，兹维·格罗斯曼及其同事认为，观察到的下降是由正在进行的感染周期的动力学所解释的。残留的细胞间感染越来越难以阻断，这可能会使细胞前病毒库稳定下来。
