Moore M A, Park C B, Tsuda H
Division of Chemotherapy, National Cancer Research Center, Tokyo, Japan.
Eur J Cancer Prev. 1998 Apr;7(2):89-107.
Recent epidemiological evidence points to a link between non-insulin dependent diabetes mellitus type II (NIDDM) and cancer of the colon, liver, pancreas, breast and endometrium. This appears to be due to the long period of hyperinsulinaemia which precedes the clinical phase of NIDDM, insulin promoting colon tumour development as well as acting as a hepatocarcinogen. Indeed, the hormone could play a central role in neoplasia, and its influence could explain the observed enhancing effects of obesity and a high fat diet, as well as the inhibition associated with physical exercise, dehydroepiandrosterone administration and high soluble fibre intake. Measures to decrease insulin levels, including lifestyle improvement and supplementation with agents known to decrease insulin resistance may therefore offer a general approach to prevention of cancer in a wide variety of organ sites of major clinical importance.
近期的流行病学证据表明，非胰岛素依赖型II型糖尿病（NIDDM）与结肠癌、肝癌、胰腺癌、乳腺癌和子宫内膜癌之间存在联系。这似乎是由于在NIDDM临床阶段之前存在的长时间高胰岛素血症，胰岛素既促进结肠肿瘤的发展，又充当肝癌致癌物。事实上，这种激素可能在肿瘤形成中起核心作用，其影响可以解释所观察到的肥胖和高脂肪饮食的促进作用，以及与体育锻炼、服用脱氢表雄酮和高可溶性纤维摄入相关的抑制作用。因此，降低胰岛素水平的措施，包括改善生活方式和补充已知可降低胰岛素抵抗的药物，可能为预防多种具有重要临床意义的器官部位的癌症提供一种通用方法。
