Bara-Jimenez W, Catalan M J, Hallett M, Gerloff C
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA.
Ann Neurol. 1998 Nov;44(5):828-31. doi: 10.1002/ana.410440520.
Abnormalities of the sensory system have been proposed as causative factors for dystonia By mapping the human cortical hand somatosensory area of 6 patients with focal dystonia of the hand, we found an abnormality of the normal homuncular organization of the finger representations in the primary somatosensory cortex (S1). Although a remote antecedent event or even a developmental anomaly cannot entirely be ruled out, our findings may support the concept that abnormal plasticity is involved in the development of dystonia.
感觉系统异常已被提出作为肌张力障碍的致病因素。通过绘制6例手部局灶性肌张力障碍患者的人类皮质手部躯体感觉区，我们发现在初级躯体感觉皮层（S1）中，手指代表区的正常同形结构存在异常。尽管不能完全排除远期既往事件甚至发育异常，但我们的发现可能支持异常可塑性参与肌张力障碍发生发展的概念。
